(…) molecular integrity and functional potency of its bioactives. As the self-microencapsulated particles enter the small intestine—where pH levels progressively shift from the acidic environment of the stomach to the mildly alkaline conditions of the duodenum and jejunum—the encapsulation layers undergo selective degradation, enabling a gradual, localized release of polyphenols in their most bioavailable form. This autonomous breakdown mechanism prolongs intestinal residence time, preventing premature excretion and maximizing interaction with enterocytes at key absorption sites. Here, bioactives are efficiently transported across the intestinal epithelium through passive diffusion, carrier-mediated pathways, and active uptake mechanisms, facilitating their rapid integration into systemic circulation.  Once absorbed, polyphenols and other bioactives bind to plasma proteins and lipoproteins, enhancing stability, bioefficacy and performance, enabling autonomous organ-specific delivery, where they exert potent antioxidant, anti-inflammatory, and metabolic regulatory effects. This advanced delivery mechanism significantly enhances cardiovascular function by improving endothelial health, modulating oxidative stress, and reducing systemic inflammation, while also crossing the blood-brain barrier to provide neurological benefits, combating neurodegeneration, cognitive decline, and neuroinflammation. Additionally, by directly interacting with insulin receptors and mitochondrial pathways, these bioactives optimize    metabolic   function,   improving  glucose     homeostasis,     lipid (…)