The incorporation of biogrape™ into a skin purification nutricosmetic powder delivers a therapeutically relevant, whole-body approach to detoxification and skin clarity by targeting the gut–liver–skin axis through a multifunctional matrix of polyphenols, fibers, fatty acids, and proteins. Derived from upcycled grape pomace and processed using a Residue-Free, Chemical-Free, and Water-Free method, biogrape™ maintains its ultrafine particle structure (~P90 = 20 µm) and full bioactive spectrum—resveratrol, quercetin, catechins, antioxidant dietary fibers, Omega-3, -6, and -9 fatty acids, and bioavailable proteins. Upon ingestion, it activates a self-microencapsulation mechanism that forms gastric-resistant protective microbarriers, allowing pH-responsive release in the small intestine and maximizing systemic absorption. Once delivered, polyphenols stimulate hepatic phase I and II detoxification enzymes, increase bile flow, and neutralize reactive intermediates, accelerating the safe breakdown and elimination of toxins, metabolic waste, and hormonal residues. This internal cleansing reduces systemic inflammation that often manifests in acne, dullness, or redness. Concurrently, biogrape™’s prebiotic fibers enhance microbial diversity and boost SCFA production—particularly butyrate and propionate—strengthening the intestinal barrier, minimizing endotoxemia, and modulating immune responses. Omega fatty acids support membrane integrity, regulate eicosanoid balance, and reduce inflammatory triggers, while protein fractions contribute to tissue repair, enzyme activity, and cytokine regulation, reinforcing the skin’s defensive and regenerative capacity. Tailored for individuals exposed to environmental toxins or managing skin conditions linked to systemic imbalance, this powder provides a clean-label, non-invasive strategy to purify from within. With regular use, it promotes clearer tone, reduced reactivity, and improved skin texture, redefining purification not as superficial cleansing but as deep, regenerative renewal driven by biogrape™’s systemic dermonutritional intelligence.
