This stage ensures that functional value is intrinsically linked to clean-label positioning, performance consistency, and market differentiation—allowing every formulation to embody both scientific intent and commercial relevance. The Science pillar provides the rigorous foundation, integrating systems biology, advanced chemistry, materials science, and nutritional biophysics. This multidisciplinary approach validates the safety, bioactivity, structural integrity, and physiological relevance of each formulation. It ensures that product performance is not only theoretically grounded, but also resilient across variables such as stability, bioavailability, and absorption kinetics—especially in food, cosmetic, nutraceutical, and nutricosmetic contexts. The Technology pillar bridges innovation and industrialization. Applied within the field of Food Science & Technology, this framework optimizes ingredient functionality, nutritional retention, and sensory expression. Innovations such as intelligent packaging and bioactive particle stabilization protect vulnerable compounds like polyphenols, vitamins, and essential fatty acids from oxidative and thermal degradation. This not only extends shelf life and enhances nutritional density but also reduces food waste and supports supply chain resilience in an increasingly climate-impacted world. In Cosmetic   Science   &   Technology,  the  methodology  empowers  the  development  of (…)