(…) cohesive protective layer in the stomach, delaying gastric clearance, optimizing macronutrient digestion, and prolonging enzymatic activity—extending satiety duration, stabilizing energy flux, and reducing caloric demand per meal cycle. Beyond satiety, biogrape™ plays a critical role in glycemic stabilization—preventing glucose surges that fuel reward-driven eating, destabilize energy balance, and promote insulin desensitization. Its polyphenolic matrix—comprising flavonoids, phenolic acids, and oligomeric proanthocyanidins—preserves epithelial resilience against oxidative stress, fortifies gut barrier function, and enhances enteric-neuronal communication for improved nutrient assimilation and appetite regulation. biogrape™’s prebiotic fibers foster the growth of symbiotic microbiota, catalyzing SCFA synthesis (acetate, propionate, butyrate), which bind to GPCRs to enhance barrier integrity, modulate lipid-glucose metabolism, and reinforce satiety circuits in the central nervous system. This physiologically calibrated, multi-axis mechanism enables biogrape™to deliver both acute satiety effects and sustained dietary regulation—modulating sugar intake kinetics, stabilizing insulin demand, and mitigating the risk of metabolic disorders such as obesity, IR (Insulin Resistance), and T2D (Type 2 Diabetes). This integrative metabolic framework positions biogrape™ as a next-generation functional ingredient—advancing glycemic and appetite regulation, promoting systemic nutritional resilience, and delivering scalable solutions for sustainable health optimization.